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rat cardiac fibroblast cell complete medium  (Procell Inc)

 
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    Structured Review

    Procell Inc rat cardiac fibroblast cell complete medium
    Venn diagram of MG-EWE active ingredient targets and proteins related to IL-6 production in cardiac <t>fibroblasts.</t>
    Rat Cardiac Fibroblast Cell Complete Medium, supplied by Procell Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rat cardiac fibroblast cell complete medium/product/Procell Inc
    Average 86 stars, based on 1 article reviews
    rat cardiac fibroblast cell complete medium - by Bioz Stars, 2026-05
    86/100 stars

    Images

    1) Product Images from "Cinnamomum migao H.W. Li Ethanol-Water Extract Suppresses IL-6 Production in Cardiac Fibroblasts: Mechanisms Elucidated via UPLC-Q-TOF-MS, Network Pharmacology, and Experimental Assays"

    Article Title: Cinnamomum migao H.W. Li Ethanol-Water Extract Suppresses IL-6 Production in Cardiac Fibroblasts: Mechanisms Elucidated via UPLC-Q-TOF-MS, Network Pharmacology, and Experimental Assays

    Journal: Current Issues in Molecular Biology

    doi: 10.3390/cimb47100798

    Venn diagram of MG-EWE active ingredient targets and proteins related to IL-6 production in cardiac fibroblasts.
    Figure Legend Snippet: Venn diagram of MG-EWE active ingredient targets and proteins related to IL-6 production in cardiac fibroblasts.

    Techniques Used:

    The schematic diagram illustrates the molecular mechanism through which MG suppresses IL-6 production in cardiac fibroblasts (CFs): in the isoproterenol (ISO)-induced CFs transdifferentiation model, MG-EWE and its active components Laurolitsine and Hecogenin can inhibit the abnormal activation of the ADRB2/JNK/c-Jun signaling pathway. When ISO binds to the ADRB2 receptor on the cell membrane surface of CFs, it initiates a downstream signaling cascade. Activation of this receptor leads to the phosphorylation of key signaling molecules, including JNK1/2/3 and c-Jun, thereby activating the JNK/c-Jun signaling pathway. The activated JNK1/2/3 translocates from the cytoplasm to the nucleus and further phosphorylates the transcription factor c-Jun within the nucleus, enhancing its transcriptional activity. This ultimately promotes the transcription of the IL-6 gene and increases its protein expression. Laurolitsine functions by inhibiting the activation of ADRB2 on the CFs cell membrane surface, while Hecogenin inhibits the phosphorylation of JNK, thereby blocking the subsequent phosphorylation of c-Jun. Together, these actions result in the joint inhibition of IL-6 production.
    Figure Legend Snippet: The schematic diagram illustrates the molecular mechanism through which MG suppresses IL-6 production in cardiac fibroblasts (CFs): in the isoproterenol (ISO)-induced CFs transdifferentiation model, MG-EWE and its active components Laurolitsine and Hecogenin can inhibit the abnormal activation of the ADRB2/JNK/c-Jun signaling pathway. When ISO binds to the ADRB2 receptor on the cell membrane surface of CFs, it initiates a downstream signaling cascade. Activation of this receptor leads to the phosphorylation of key signaling molecules, including JNK1/2/3 and c-Jun, thereby activating the JNK/c-Jun signaling pathway. The activated JNK1/2/3 translocates from the cytoplasm to the nucleus and further phosphorylates the transcription factor c-Jun within the nucleus, enhancing its transcriptional activity. This ultimately promotes the transcription of the IL-6 gene and increases its protein expression. Laurolitsine functions by inhibiting the activation of ADRB2 on the CFs cell membrane surface, while Hecogenin inhibits the phosphorylation of JNK, thereby blocking the subsequent phosphorylation of c-Jun. Together, these actions result in the joint inhibition of IL-6 production.

    Techniques Used: Activation Assay, Membrane, Phospho-proteomics, Activity Assay, Expressing, Blocking Assay, Inhibition



    Similar Products

    rat cardiac fibroblast cell complete medium  (Procell Inc)
    86
    Procell Inc rat cardiac fibroblast cell complete medium
    Venn diagram of MG-EWE active ingredient targets and proteins related to IL-6 production in cardiac <t>fibroblasts.</t>
    Rat Cardiac Fibroblast Cell Complete Medium, supplied by Procell Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rat cardiac fibroblast cell complete medium/product/Procell Inc
    Average 86 stars, based on 1 article reviews
    rat cardiac fibroblast cell complete medium - by Bioz Stars, 2026-05
    86/100 stars
    		  Buy from Supplier

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    Venn diagram of MG-EWE active ingredient targets and proteins related to IL-6 production in cardiac fibroblasts.

    Journal: Current Issues in Molecular Biology

    Article Title: Cinnamomum migao H.W. Li Ethanol-Water Extract Suppresses IL-6 Production in Cardiac Fibroblasts: Mechanisms Elucidated via UPLC-Q-TOF-MS, Network Pharmacology, and Experimental Assays

    doi: 10.3390/cimb47100798

    Figure Lengend Snippet: Venn diagram of MG-EWE active ingredient targets and proteins related to IL-6 production in cardiac fibroblasts.

    Article Snippet: Rat Cardiac Fibroblast Cells (CP-R074) and Rat Cardiac Fibroblast Cell Complete Medium (CM-R074) were purchased from Wuhan Procell Life Science & Technology Co., Ltd. (Wuhan, Hubei, China).

    Techniques:

    The schematic diagram illustrates the molecular mechanism through which MG suppresses IL-6 production in cardiac fibroblasts (CFs): in the isoproterenol (ISO)-induced CFs transdifferentiation model, MG-EWE and its active components Laurolitsine and Hecogenin can inhibit the abnormal activation of the ADRB2/JNK/c-Jun signaling pathway. When ISO binds to the ADRB2 receptor on the cell membrane surface of CFs, it initiates a downstream signaling cascade. Activation of this receptor leads to the phosphorylation of key signaling molecules, including JNK1/2/3 and c-Jun, thereby activating the JNK/c-Jun signaling pathway. The activated JNK1/2/3 translocates from the cytoplasm to the nucleus and further phosphorylates the transcription factor c-Jun within the nucleus, enhancing its transcriptional activity. This ultimately promotes the transcription of the IL-6 gene and increases its protein expression. Laurolitsine functions by inhibiting the activation of ADRB2 on the CFs cell membrane surface, while Hecogenin inhibits the phosphorylation of JNK, thereby blocking the subsequent phosphorylation of c-Jun. Together, these actions result in the joint inhibition of IL-6 production.

    Journal: Current Issues in Molecular Biology

    Article Title: Cinnamomum migao H.W. Li Ethanol-Water Extract Suppresses IL-6 Production in Cardiac Fibroblasts: Mechanisms Elucidated via UPLC-Q-TOF-MS, Network Pharmacology, and Experimental Assays

    doi: 10.3390/cimb47100798

    Figure Lengend Snippet: The schematic diagram illustrates the molecular mechanism through which MG suppresses IL-6 production in cardiac fibroblasts (CFs): in the isoproterenol (ISO)-induced CFs transdifferentiation model, MG-EWE and its active components Laurolitsine and Hecogenin can inhibit the abnormal activation of the ADRB2/JNK/c-Jun signaling pathway. When ISO binds to the ADRB2 receptor on the cell membrane surface of CFs, it initiates a downstream signaling cascade. Activation of this receptor leads to the phosphorylation of key signaling molecules, including JNK1/2/3 and c-Jun, thereby activating the JNK/c-Jun signaling pathway. The activated JNK1/2/3 translocates from the cytoplasm to the nucleus and further phosphorylates the transcription factor c-Jun within the nucleus, enhancing its transcriptional activity. This ultimately promotes the transcription of the IL-6 gene and increases its protein expression. Laurolitsine functions by inhibiting the activation of ADRB2 on the CFs cell membrane surface, while Hecogenin inhibits the phosphorylation of JNK, thereby blocking the subsequent phosphorylation of c-Jun. Together, these actions result in the joint inhibition of IL-6 production.

    Article Snippet: Rat Cardiac Fibroblast Cells (CP-R074) and Rat Cardiac Fibroblast Cell Complete Medium (CM-R074) were purchased from Wuhan Procell Life Science & Technology Co., Ltd. (Wuhan, Hubei, China).

    Techniques: Activation Assay, Membrane, Phospho-proteomics, Activity Assay, Expressing, Blocking Assay, Inhibition